Emerging scaffold- and cellular-based strategies for brain tissue regeneration and imaging

Abstract Stimulating brain tissue regeneration is a major challenge after central nervous system (CNS) injury, such as those observed from trauma or cerebrovascular accidents. Full difficult even when neurogenesis-associated repair response may occur. Currently, there are no effective treatments to stimulate regeneration. However, biomaterial scaffolds showing promising results, where hydrogels the materials of choice develop these supportive for cell carriers. Their combination with growth factors, brain-derived neurotrophic factor (BDNF), basic fibroblast (bFGF), vascular endothelial (VEGF), together other therapy strategies allows prevention further neuronal death and can potentially lead direct stimulation neurogenesis vascularisation at injured site. Imaging site particularly critical study reestablishment neural functionality injury. This review outlines latest key advances associated different aiming promote neuroregeneration, imaging, functional recovery tissue. Graphical abstract